Primary cilia regulation of intercellular cytoskeletal dynamics
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The primary cilium forms a unique mechano- and chemo- signaling nexus and has been shown to be a key component of osteocyte mechanotransduction. We are investigating how the primary cilium with a highly regulated transport system, contributes to whole cell response to mechanical loading. We are investigating this at the in vitro and in vivo level. Work on this project will include immunocyto/histo chemistry to stain and track key proteins, epifluorescence and confocal imaging, image analysis, genotyping, electroporation, and real-time imaging with fluorescent cytoskeletal probes.