Investigating Bag3 in Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is a form of cardiomyopathy characterized by poor ventricular contractility that commonly originates from genetic mutations. Mutations in Bcl2-associated athanogene 3 (Bag3), a co-chaperone of the heat shock proteins that regulates protein quality control, have been found to cause adult onset DCM. This project aims to find and understand the pathways modulating Bag3 mediated dilated cardiomyopathy. This project will involve using molecular biology and tissue engineering to create and analyze models.

Lab: Lab for Laboratory for Stem Cells and Tissue Engineering

Direct Supervisor: Sue Halligan

Position Dates: Summer 2022

Hours per Week: 20

Number of positions: 1

Qualifications: Student must have basic knowledge of cell culture, sterile technique and cardiac tissue engineering models model systems. Advanced skills in tissue preparation is a plus. 

Eligibility: Junior (SEAS only)

Sue Halligan, [email protected]