Engineering Vascularized Organoid Models

Our lab is at the interface of chemical/biological engineering and developmental biology, with a broader goal of building sophisticated ex vivo models of human organ development. We study early embryonic development with a focus on embryonic and placental patterning, early organ specification, and complex tissue interactions. For instance, to create more accurate versions of human organs in a lab, we mimic actual organ development by using embryonic stem cells and differentiating them inside precise microfluidics signaling gradients, and we employ biomaterials and tissue engineering to manipulate the 3D shape of tissues. For this project, we are looking for a student who will expand on the complexity of our ex vivo organ models by building complex 3D vasculature using a combination of tissue and genetic engineering.

Name of Lab: Laboratory of Synthetic Human Organogenesis

Direct Supervisor: Miaoci Zhao

Hours per week: 20 hr/week

Position type: On site

Qualifications: basic wet lab skills

Eligibility: Sophomore, Junior, Senior

SEAS students only: Yes

Mijo Simunovic, [email protected]