Effects of Galactic Radiation on a Human Multi-Organ-on-a-Chip System

The research project will entail studying the effects of cosmic radiation on a multi-organ-on-a-chip system in vitro, engineered with human tissue models of the bone marrow, liver, heart, and vasculature. Under a NASA and Translational Research Institute for Space Health consortium, and working with a number of Columbia collaborators, we are studying specifically how doses of simulated galactic cosmic radiation may impact human tissue function, structure, and transcriptome after 2-4 weeks of radiation exposure. The research assistant will help design and culture tissue platforms, as well as analyze engineered tissue samples after exposures. The project will culminate with a critical titration experiment for optimal dosing of radioprotective cytokine G-CSF in response to protracted radiation exposures.

Lab: Lab for Laboratory for Stem Cells and Tissue Engineering

Direct Supervisor: Sue Halligan

Position Dates: Summer 2022

Hours per Week: 20

Number of positions: 1

Qualifications: Student must have basic knowledge of cell culture, sterile technique and organ-on-chip model systems. Advanced skills in tissue preparation is a plus. 

Eligibility: Master's (SEAS only)

Sue Halligan, [email protected]