CAR T cell immunotherapy treats leukemia by expanding the patient's own T cells in large quantities ex vivo before modifying their T cell receptors to better target the cancer. However, patients with advanced disease have poor starting T cell quantity and quality, often resulting in the patients to be ineligible for the life changing treatment. We will study the exhaustion phenotype in Chronic Lymphocytic Leukemia (CLL) patient T cells, to better understand why CLL T cells don’t expand as well as healthy cells and also to characterize T cell exhaustion. We will use injection molded microwells specially designed to allow imaging of small numbers of cells to conserve the scarce patient samples while testing multiple conditions at once.
Lab: Microscale Biocomplexity Laboratory, Lance Kam
Direct Supervisor: Joanne Lee
Position Dates: 5/20/2019 - 8/9/2019
Hours per Week: 40
Paid Position: Yes
Qualifications: Biology, laboratory safety and techniques
Eligibility: Freshman, Sophomore, Junior (SEAS only)